Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein
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Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein
Olopatadine hydrochloride (olopatadine) is an antiallergic drug with histamine H(1) receptor antagonistic activity. Recently, olopatadine has been shown to bind to S100A12 which is a member of the S100 family of calcium-binding proteins, and exerts multiple proinflammatory activities including chemotaxis for monocytes and neutrophils. In this study, we examined the possibility that the interact...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 2006
ISSN: 0962-9351,1466-1861
DOI: 10.1155/mi/2006/42726